Medeama lost 3-1 at Techiman Eleven Wonders to leave the final game of the season against Berekum Chelsea all to play for.
Striker Prince Opoku Agyemang climbed off the bench to score the consolation seven minutes into injury time.
Wonders midfielder Tetteh Nortey opened the scoring as early as the fourth minute with the opener.
Referee Isaac Osei awarded a dubious penalty to the host which was expertly converted by Kwame Simms on 48 minute.
Abass Ganiu scored the third again through a contentious penalty with one minute left on the regulation time before Prince Opoku Agyemang climbed off the bench to score the consolation seven minutes into injury time.
Referee Isaac Osei will come in for a lot of flak for his poor performance at the Nana Ameyaw Park.